Immunohistochemistry Newsletter


Rodney T. Miller, M.D.

Director of Immunohistochemistry

ProPath Laboratory




July 2007 Immunohistochemistry in the diagnosis of Lyme Disease
June 2007 Phospho-STAT5 Immunostains as a Surrogate Marker for JAK2 V617F Mutations in non-CML Chronic Myeloproliferative Disorders
May 2007 TLE1 Immunostains in the Diagnosis of Synovial Sarcoma
Apr 2007 PAX-5
Mar 2007 The Role of Immunohistochemistry for ERCC1 in Determining Therapeutic Response in Non-Small Cell Lung Carcinomas
Feb 2007 Immunohistochemistry in the Diagnosis of Whipple's Disease
Jan 2007 Update on Immunohistochemistry of Germ Cell Tumors
Dec 2005 MDM2 and CDK 4 immunostains in the diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma
Nov 2005 Annexin A1: A New Marker for Hairy Cell Leukemia
Oct 2005 Utility of immunostains for D2-40 in diagnostic pathology
Sept 2005 Immunohistochemical markers of prostate carcinoma, including prostate-specific membrane antigen (PSMA)
Aug 2005 Platelet derived growth factor receptor alpha (PDGFR-α) immunostains in the identification of c-kit negative gastrointestinal stromal tumors (GISTs)
July 2005 Immunohistochemistry in the Recognition of “Basal-like” or “Basaloid” Breast Carcinoma
June 2005

Immunohistochemical Features of Squamous Differentiation

May 2005 Immunohistochemistry in the recognition of respiratory syncytial virus (RSV) pneumonia
Apr 2005

Immunohistochemistry in the differential diagnosis of clear cell carcinomas from the kidney, liver, and lung

Mar 2005 Immunohistochemistry in dermatofibrosarcoma protuberans (DFSP) vs. dermatofibroma-fibrous histiocytoma (DF-FH)
Feb 2005 Ki-67 clone K-2: A useful marker of fat cells and lipoblasts
Jan 2005 Cytopathology-from an Immunohistochemist's Perspective
Dec 2004 Immunohistochemistry in the Differential Diagnosis of Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma
Nov 2004 Immunohistochemistry in the Recognition of Early Myocardial Infarction
Oct 2004 Immunohistochemistry in the Differential Diagnosis of Schwannoma and Neurofibroma
Sep 2004 Immunohistochemistry in Amyloidosis
Aug 2004 Differential Diagnosis of Cytokeratin "Dots"
Jul 2004

Immunostains for B-catenin in Diagnostic Pathology

Jun 2004 Using fluorescent in situ hybridization (UroVysion FISH) for monitoring of recurrence of urothelial carcinoma
May 2004 Oct 3/4: A New Marker of Embryonal Carcinoma and Seminoma
Apr 2004 p63/P504S Antibody Cocktail in Prostate Biopsies
Mar 2004 Epidermal Growth Factor Receptor and Erbitux
Feb 2004 Perivascular Epithelioid Cell Tumors (PE Comas)
Jan 2004 Endogenous Biotin Artifact
Dec 2003 ZAP-70 in Chronic Lymphocytic Leukemia
Nov 2003

Cytokeratin AE1/AE3

Oct 2003 Immunohistochemistry in the Evaluation of Follicular or Nodular Lymphoid Lesions
Sep 2003 Immunohistochemistry in Lymph Node Histiocytosis
Aug 2003 Immunohistochemistry in the Evaluation of Atypical Epithelial Cells in Effusions
Jul 2003 TFE3 Immunostains in the Diagnosis of Alveolar Soft Part Sarcoma and Other Tumors
Jun 2003 Immunohistochemistry in Urothelial Dysplasia
May 2003 Anaplastic Lymphoma Kinase (ALK)
Apr 2003 Endocervical vs. Endometrial Adenocarcinoma: Update on Useful Immunohistochemical Markers
Mar 2003 Evaluation of Hydropic Placentas (Hydropic Degeneration vs. Partial Mole vs. Complete Mole)
Feb 2003 Calretinin
Jan 2003 Immunohistochemistry in Forensic Pathology
Dec 2002 CDX2
Nov 2002 P504S
Oct 2002 Utility of Ki-67 (MIB-1) Immunostaining in Cervical Biopsies
Sep 2002 Utility of p16 (INK4a) Immunostaining in Cervical Biopsies
Aug 2002

Ubiquitin Immunohistochemistry in Alzheimer's Disease

Jul 2002

Breast Carcinoma vs. Pulmonary Adenocarcinoma

Jun 2002 Human Herpesvirus Type 8 (HHV8)
May 2002 High Molecular Weight Cytokeratin (34ßE12)
Apr 2002 Optimal Titering of Primary Antibodies (And the Dangerous Fallacy of "Predilute Ready-to-Use" Antibodies)
Mar 2002

Tissue Protection Immunohistochemistry

Feb 2002 Recognition of Gluten Sensitivity
Jan 2002

Endocervical vs. Endometrial Adenocarcinoma

Dec 2001 True Positive vs. False Positive Staining
Nov 2001

Traps in Sentinel Lymph Node Biopsies

Oct 2001 Wilms Tumor Gene Protein (WT1)
Sep 2001 p63
Aug 2001


Jul 2001 BCL-2
Jun 2001 Villin
May 2001


Apr 2001

Thyroid Transcription Factor-1 (TTF-1)

Mar 2001

Poorly Differentiated Prostate Adenocarcinoma Vs. Urothelial Carcinoma

Feb 2001

Immunophenotype of Renal Cell Carcinoma, "Clear Cell" Type

Jan 2001

hMLH1 and hMSH2: Important Immunohistochemical Markers for the Evaluation of Patients with Possible Hereditary Non-Polyposis Colon Cancer Syndrome

Dec 2000

Cytokeratin 5/6

Nov 2000

Gastrointestinal Stromal Tumors (GIST)

Oct 2000

Squamous Carcinoma vs. Poorly Differentiated GI Adenocarcinoma vs. Small Cell Carcinoma

Sep 2000

Antibodies Useful in the Diagnosis of Cutaneous Paget's Disease

Aug 2000

E-Cadherin: An Aid in Distinguishing Ductal from Lobular Breast Proliferations

Jul 2000

Myoepithelial Markers: An Aid in the Interpretation of Breast Biopsies

Jun 2000

Cat Scratch Disease Antibody Now Available


We are very grateful for Dr. Rodney T. Miller generous contribution of his newsletters. Please visit for more information and updates.