Bcl-3 Oncoprotein Antibody Staining Protocol for Immunohistochemistry

Description: Bcl-3 was first identified as a putative proto-oncogene and was originally isolated though its involvement in the translocation t(14;19). The Bcl-3 gene product is also thought to play a role in the immune system through its interactions with the NF-kappaB family of transcription factors, to enhance proliferation and to act as a transcription cofactor. More specifically, Bcl-3 appears to regulate the activity of homodimeric NF-kappaB p50 subunit and a closely-related homolog, p52, in a phosphorylation-dependent manner. Bcl-3 mRNA is found in a number of tissues, including spleen and other lymphoid tissues.