Bcl-rambo Antibody Staining Protocol for Immunohistochemistry

Description: Bcl-rambo is a member of the Bcl-2 family of proteins which plays a central regulatory role in apoptosis. In mammalian cells, Bcl-rambo is localised to mitochondria where its overexpression induces apoptosis. Bcl-rambo cell death activity is induced through its membrane-anchored C-terminal domain and not by the Bcl-2 homologous region. This C-terminal membrane anchor and its unique extension region is important for pro-apoptotic activity inducing caspase-3 activation. Bcl-rambo mRNA is reported to be found in a diverse range of tissues, with the highest levels detected in heart, pancreas, placenta and skeletal muscle. Bcl-rambo mRNA has also been found in brain, liver and kidney.