Calbindin Antibody Staining Protocol for Immunohistochemistry

Description: Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It functions as a buffer for cytoplasmic calcium and is found in the brain, kidney, gut and pancreatic islets. In normal brain, calbindin has been identified in medium sized neurons of the neuropil of the matrix compartment of the striatum, the woolly fibre arrangements of the globus pallidus and the fibre structures of the pars reticula of the substantia nigra. A proportion of dendritic cells within the light zone of germinal centres have also been noted to be positive for calbindin.