Collagen Type IV IHC Antibody, Ready to Use

 

Collagen Type IV IHC Antibody

 

Ready To Use

 

Catalog Number Size Price Availability
IW-MA1030 9 ml $258 Yes

Description

 

Collagen IV is comprised of a third chain (alpha-3) together with the 2 classical ones, alpha-1 and alpha-2. COL4A3 gene is localized to 2q36-q37 by analysis of somatic cell hybrids and by in situ hybridization. The alpha-3 chain of type IV collagen induces autoimmune Good pasture syndrome. Mutations in the COL4A4 and COL4A3 genes cause familial benign hematuria.

 

Catalog Number

 

IW-MA1030

Quantity

 

9 ml

Host

 

Mouse

 

Clone

 

Col-30

 

Isotype

 

Mouse IgG1

 

Immunogen

 

Human collagen type IV

 

Purity

 

Purified by the goat anti-mouse IgG affinity chromatography.

Conjugate

 

Unconjugated

 

Species Reactivity

 

Human, rat. Not tested in other species.

Positive Control

 

Human mammary cancer, kidney, skin

 

Cellular Localization

 

Cytoplasmic

 

Form

 

Ready to use solution. No further dilution needed. Serum blocking step should be omitted.

 

Storage

 

Store at 2-8 °C. Do not freeze.

 

Applications

 

IHC-P: Formalin fixed paraffin embedded tissue sections.

IHC-Fr: Formalin or acetone fixed frozen sections.

ICC: Not tested.

 

Limitations

 

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

 

Precautions

 

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

 

References

 

1. Kalluri, R.; Gattone, V. H., II; Noelken, M. E.; Hudson, B. G. : The alpha-3 chain of type IV collagen induces autoimmune Goodpasture syndrome. Proc. Nat. Acad. Sci. 91: 6201-6205, 1994.

2. Badenas, C.; Praga, M.; Tazon, B.; Heidet, L.; Arrondel, C.; Armengol, A.; Andres, A.; Morales. E.; Camacho, J. A.; Lens, X.; Davila, S.; Mila, M.; Antignac, C.; Darnell, A.; Torra, R. : Mutations in the COL4A4 and COL4A3 genes cause familial benign hematuria. J. Am. Soc. Nephrol. 13: 1248-1254, 2002.

 

Images

 

Immunohistochemical analysis of formalin fixed paraffin-embedded human mammary cancer using Collagen Type IV antibody.

 

 

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