TH (Tyrosine Hydroxylase) IHC Antibody, Ready to Use

 

TH IHC Antibody

 

Ready To Use

 

Catalog Number Size Price Availability
IW-MA1100 9 ml $258 Yes

Description

Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Human TH gene contains 13 primary exons and spans approximately 8 kb. TH is in the 11p15.5 region.

Catalog Number

IW-MA1100

 

Quantity

9 ml

 

Host

Mouse

 

Clone

TH-100

 

Isotype

Mouse IgG1

 

Immunogen

Rat tyrosine hydroxylase (TH)

 

Purity

Purified by the goat anti-mouse IgG affinity chromatography.

 

Conjugate

Unconjugated

 

Species Reactivity

Human, rat. Not tested in other species.

 

Positive Control

Brain (striatum, substantia nigra)

 

Cellular Localization

Cytoplasmic of dopamine neurons.

 

Form

Ready to use solution. No further dilution needed. Serum blocking step should be omitted.

 

Storage

Store at 2-8 °C. Do not freeze.

 

Applications

IHC-P: Heat induced epitope retrieval is required on formalin fixed paraffin embedded sections.

IHC-Fr: Formalin or acetone fixed frozen sections.

ICC: Not tested.

 

Limitations

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

 

Precautions

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

 

References

1. Brilliant, M. H.; Niemann, M. M.; Eicher, E. M. : urine tyrosine hydroxylase maps to the distal end of chromosome 7 within a region conserved in mouse and man. J. Neurogenet. 4: 259-266, 1987.

2. Craig, S. P.; Buckle, V. J.; Craig, I. W.; Lamouroux, A.; Mallet, J. : Localization of the human tyrosine hydroxylase gene to chromosome 11p15. (Abstract) Cytogenet. Cell Genet. 40: 610 only, 1985.

3. Craig, S. P.; Buckle, V. J.; Lamouroux, A.; Mallet, J.; Craig, I. : Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. Cytogenet. Cell Genet. 42: 29-32, 1986.

 

Images

Immunohistochemical staining of formalin fixed paraffin-embedded rat brain using TH antibody showing cytoplasmic staining pattern. DAB chromogen substrate. 

 

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