 |
TNF-alpha IHC Antibody
Ready To Use
| Catalog Number | Size | Price | Availability |
| IW-PA1079 | 9 ml | $258 | Yes |
Description
|
Tumor necrosis factor-alpha (TNFA) also known as TNFR1, It
is a potent cytokine, elicits a broad spectrum of biologic
responses that are mediated by binding to a cell surface
receptor. There are 2 different proteins that serve as major
receptors for TNF-alpha, one associated with myeloid cells
and one associated with epithelial cells. TNFR1 maps to
12p13. TNFR1 signaling is also known to activate the
transcription factor NF-kappa B and promote survival. |
Catalog Number
|
IW-PA1079 |
Quantity
|
9 ml |
|
Host |
Rabbit |
|
Clone |
Polyclonal |
|
Isotype |
IgG |
|
Immunogen |
A peptide mapping at the C-terminal end
of TNFα of human origin, identical to the related mouse and rat
sequence. |
|
Purity |
Immunogen affinity purified |
|
Conjugate |
Unconjugated |
|
Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
|
Positive Control |
Human mammary cancer |
|
Cellular Localization |
Cytoplasmic |
|
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
|
Storage |
Store at 2-8
°C. Do not freeze. |
|
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested. |
|
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
|
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
|
References |
1.
Derre, J.; Kemper, O.; Cherif, D.; Nophar, Y.; Berger, R.;
Wallach, D. : The
gene for the type 1 tumor necrosis factor receptor (TNF-R1)
is localized on band 12p13.
Hum. Genet.
87: 231-233, 1991.
2.
Fuchs, P.; Strehl, S.; Dworzak, M.; Himmler, A.; Ambros, P.
F. : Structure of
the human TNF receptor 1 (p60) gene (TNFR1) and localization
to chromosome 12p13.
Genomics 13:
219-224, 1992.
3.
Micheau, O.; Tschopp, J. :
Induction of TNF
receptor I-mediated apoptosis via two sequential signaling
complexes.
Cell 114: 181-190, 2003. |
|
Images |
Immunohistochemical analysis of formalin fixed paraffin-embedded
human mammary cancer section using TNFα antibody
|
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