Tau IHC Antibody, Ready to Use

 

Tau IHC Antibody

 

Ready To Use

 

Catalog Number Size Price Availability
IW-MA1093 9 ml $258 1-2 weeks

Description

The microtubule-associated proteins (MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to be enriched in axons. Tau is composed of 352 to 441 amino acids. The isoforms differ from each other by the presence or absence of 29-amino acid or 58-amino acid inserts located in the N terminus and a 31-amino repeat located in the C terminus. Tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles (NFTs) characteristic of Alzheimer's brain. Microtubule-associated protein tau (MTBT1) is mapped to chromosome 17q21.

 

Catalog Number

IW-MA1093

 

Quantity

9 ml

 

Host

Mouse

 

Clone

TAU-93

 

Isotype

Mouse IgG1

 

Immunogen

Bovine microtubule-associated proteins (MAPs).

 

Purity

Purified by the goat anti-mouse IgG affinity chromatography.

 

Conjugate

Unconjuated

 

Species Reactivity

Human, mouse, rat. Not tested in other species.

 

Positive Control

Alzheimer’s brain tissue (neurofibrillary tangles, senile plaques).

 

Cellular Localization

Cytoplasmic

 

Form

Ready to use solution. No further dilution needed. Serum blocking step should be omitted.

 

Storage

Store at 2-8 °C. Do not freeze.

 

Applications

IHC-P: Heat induced epitope retrieval is required on formalin fixed paraffin embedded sections.

IHC-Fr: Not tested.

ICC: Not tested.

 

Limitations

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

 

Precautions

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

 

References

1. Andreadis, A.; Brown, W. M.; Kosik, K. S. : Structure and novel exons of the human tau gene. Biochemistry 31: 10626-10633, 1992.

2. Donlon, T. A.; Harris, P.; Neve, R. L. : Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21. (Abstract) Cytogenet. Cell Genet. 46: 607, 1987.

 

Images

Immunohistochemical staining of formalin fixed paraffin-embedded human brain using Tau antibody. DAB chromogen substrate. 

 

 

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