ABC of Safety in the Biological Sciences
CATEGORY B1 PATHOGENS
This includes organisms, viruses and
material which offers special hazards to workers in the biological
sciences and for which special accommodation and conditions for
containment must be provided for by law in most countries of the
The human pathogens and hazardous material
in this category are:
- Bartonella spp.
- Brucella spp.
- Clostridium otulinum.
- Francisella tularensis.
- Mycobacterium tuberculosis and other
species of pathogenic mycobacterium.
- Pseudomonas mallei.
- Pseudomonas pseudomallei.
- Salmonella paratyphi A.
- Salmonella typhi.
- Yersinia pestis.
- Blastomyces dermatitidis.
- Coccidioides immitis.
- Cryptococcus neoformans.
- Histoplasma capsulatum and related
- Paracoccidioides brasiliensis.
- Chlamydia psittaci.
- Coxiella burneti and other pathogenic
- Legionella pneumophila.
- Arboviruses except Semlike Forest,
Uganda S, Langate and Yellow Fever.
- 17D vaccine strain and Sindbis
- All sputum and other material that
may contain tubercle bacilli, even if examination for them
has not been required, must be processed in an exhaust
protective cabinet in Category B1 accommodation.
- Materials and reagents known to
contain Hepatitis B virus. Material known to contain
Hepatitis B surface antigen when it is deliberately brought
into a laboratory as test material or as a control.
- Brain tissue and spinal cord
material from patients with CreutzfeldtJakob disease and
multiple sclerosis when they are subjected to homogenisation
or disruption for biochemical or research purposes.
All specimens that contain or are suspected
of containing organisms, viruses and materials in Category B1 must
be labelled `Danger of Infection' on both the specimen container and
the request form by the person requesting the investigation.
Miller, B.M. et al. (1986)
Laboratory Safety: Principles and Practices.
American Society for Microbiology, Washington
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