Histopathology Artifacts Quiz by Roy Ellis


Histopathology Artifacts Quiz



This slide shows areas which crystals once occupied but which dissolved during fixation and processing. The characteristic shape suggests cholesterol which is often deposited as tapering needle-crystals in vessel walls in atheroma and in various sites of old haemorrhage. A more common example of the loss of soluble substances is seen when neutral fat is dissolved from fat cells leaving regular ovoid spaces surrounded by a rim of cytoplasm. So the correct answer is loss of soluble substance.

© Roy C. Ellis 2004