Histopathology Artifacts Quiz



This slide shows areas which crystals once occupied but which dissolved during fixation and processing. The characteristic shape suggests cholesterol which is often deposited as tapering needle-crystals in vessel walls in atheroma and in various sites of old haemorrhage. A more common example of the loss of soluble substances is seen when neutral fat is dissolved from fat cells leaving regular ovoid spaces surrounded by a rim of cytoplasm. So the correct answer is loss of soluble substance.

© Roy C. Ellis 2004