Histopathology Discussion => Tumor and Antibody Panel => Topic started by: n_bjorkhammer on October 31, 2005, 07:26:06 AM

Title: Differential diagnosis between Gastric & Colon Carcinoma
Post by: n_bjorkhammer on October 31, 2005, 07:26:06 AM
Trying to find an antibody that can differentiate between these two tumours. The standard panel of CK7/20 wont differentiate. Any suggestions?

Thanks

Nick
Title: Re: Differential diagnosis between Gastric & Colon Carci
Post by: ImmunoNYC on November 08, 2005, 11:57:30 PM
I suggest you check out the book by David Dabbs called Diagnostic Immunopathology if you haven't already. It's fabulous.

Anyway I consulted mine and this is what it says for gastric vs colon:

It says to use the standard CK7/CK20 as you already used though it points out that CK7 and CK20 play a small role in distinguishing the two as only 10-20% of gastric adenos actually prominently show the CK7+/CK20- coordinate staining pattern. Hmm, this must be what you are seeing. Instead they mention to use CK17 as it is positive in less than 50% of gastric adenos but in the positive ones the staining pattern is strong and diffuse where colorectal tumors do not stain with CK17 or show extremely focal staining. Might be worth a shot :)
Title: Differential diagnosis between Gastric & Colon Carcinoma
Post by: JLI on November 10, 2005, 04:52:19 PM
I suggest that you add villin and CDX2 to your panel. They are both powerful markers of colorectal adenocarcinoma
Title: Re: Differential diagnosis between Gastric & Colon Carcinoma
Post by: richard03 on September 27, 2007, 10:42:30 PM
Gastric Cancer Markers
http://www.antibodybeyond.com/reviews/tumor-markers/gastric-cancer-marker.htm

Colon Cancer Markers
http://www.antibodybeyond.com/reviews/tumor-markers/colorectal-cancer-marker.htm