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Author Topic: Cytokines and Growth Factors  (Read 1337 times)

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Offline WWang1991

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Cytokines and Growth Factors
« on: March 11, 2015, 03:09:44 AM »
What's the  function of Cytokines and Growth Factors? and tell me why they are used in research?
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Cytokines and Growth Factors
« on: March 11, 2015, 03:09:44 AM »

Offline Wendy123

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Re: Cytokines and Growth Factors
« Reply #1 on: March 11, 2015, 03:46:52 AM »
Growth factors, cytokines and chemokines are crucial for coordinating multiple cell types during the healing process. Proper wound healing is guided by stringent regulation of these agents as well as a wound environment that favors their activity. As to the acute wound, the healing process is controlled by spatio-temporal action of these growth factors. Cytokines and chemokines will lead through progression of healing, resulting in the re-establishment of the skinís barrier function. Whatís more, the generation of a proteolytic environment by inflammatory cells infiltrating the wound site and the prolonged up-regulation of pro-inflammatory cytokines and chemokines will inhibit normal progression of wound healing.
 
Growth factors and cytokines released at sites of injury and inflammation play an important role in stimulating endothelial progenitor cell (EPC) migration to these sites. The comparative analysis of literature shows that under neutral in vitro conditions, several growth factors and cytokines influence favorably indices of EPC angiogenic function. While, under acidic conditions, the biological activity of certain growth factors may be impaired, although TPO, SCF and IL-3 were each able to rescue EPCs from acidic exposure apoptosis, a combination of these three factors stimulated cell proliferation and prevented apoptosis. Possible combinations of growth factors and cytokines together with EPC transplantation may provide for a greater extent of vessel repair and new vessel formation.

Offline TYuanyuan

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Re: Cytokines and Growth Factors
« Reply #2 on: June 15, 2015, 04:53:21 AM »
Cytokines modulate the balance between humoral and cell-based immune responses, and they regulate the maturation, growth, and responsiveness of particular cell populations. Some cytokines enhance or inhibit the action of other cytokines in complex ways.

Growth factors typically act as signaling molecules between cells. Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells.They often promote cell differentiation and maturation, which varies between growth factors.

Re: Cytokines and Growth Factors
« Reply #2 on: June 15, 2015, 04:53:21 AM »