Activin A is a member of the transforming growth factor β (TGF-β) superfamily. It has a wide range of biological activities including driving endoderm and mesoderm induction and regulating the differentiation of many cell types. Activin A has also been shown to support maintenance of human embryonic stem cells in the undifferentiated state. It shares receptors with the ligand nodal and activates the same downstream SMAD pathway as TGF-β. Recombinant human mature Activin A is a disulfide-linked homodimer of two 116 amino acid residue βA subunits with a molecular weight of 13 kDa.
Human Activin A expressed in CHO cells or Baculovirus-Insect Cells or Nicotiana benthamiana.
Purity:Greater than 95% as determined by SDS-PAGE and visualized by silver stain.