Proteins that bind with lipids such as fat and cholesterol are called Apolipoproteins. Their bodily function includes transportation of lipids through circulatory and lymphatic system. APOE also serve as enzyme cofactors and receptor ligands. These proteins are classified into six classes represented by A – H.
Apolipoproteins are tested for the screening of different medical conditions such as Alzheimer disease, thyroid disease and cardiovascular disease, etc.
The testing of APOE revolves around the principle of giving rise to competitive inhibition reaction between pre-coated APOE and APOE in samples. The colour development is then identified, stopped and the intensity is measured.