Author Topic: Teduglutide  (Read 498 times)

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Offline SBella

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Teduglutide
« on: February 28, 2017, 02:00:05 AM »
Teduglutide differs from natural GLP-2 by a single amino acid: an alanine is replaced with a glycine. This blocks breaking down of the molecule by dipeptidyl peptidase and increases its half-life from seven minutes (GLP-2) to about two hours, while retaining its biological actions. These include maintenance of the intestinal mucosa, increasing intestinal blood flow, reducing gastrointestinal motility and secretion of gastric acid.

Teduglutide
« on: February 28, 2017, 02:00:05 AM »