Calponin Antibody Staining Protocol for Immunohistochemistry

Description: Calponin, a calmodulin, binds tropomyosin and F-actin and is thought to be involved in the regulation of smooth muscle contraction. The expression of calponin is restricted to smooth muscle cells and is a marker of the differentiated contractile phenotype of developing smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kD and 29kD. Expression of the 29kD form is primarily restricted to muscle of the urogenital tract. The 34kD isoform is expressed in vascular and visceral smooth muscle of trachea, jejunum and oesophagus.