Beta Catenin Antibody Staining Protocol for Immunohistochemistry

Description: The catenins (α, β, γ, δ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. α-catenin also associates with P-cadherin and N-cadherin. β-catenin co-immunoprecipitates with APC. γ-catenin associates with both N-cadherin and E-cadherin and is a major component of desmosomes, where it is found complexed to desmoglein. δ-catenin interacts with Presenilin 1. A hemizygous deletion of the gene encoding δ-catenin correlates with mental retardation in cri-du-chat syndrome. Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is also a member of the catenin family that may function as a nuclear protein.