CD3 Antibody Staining Protocol for Immunohistochemistry

Description: The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kD. The five chains are designated gamma, delta, epsilon, zeta and eta. This antibody is specific for the non-glycosylated epsilon chain of the CD3 molecule. The CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage. This antibody recognizes T cells in thymus, bone marrow, peripheral lymphoid tissue and blood and detect both normal and neoplastic T cells.