Chromogranin A (CGA) Antibody Staining Protocol for Immunohistochemistry

Description: Chromogranin A is an acidic, soluble protein first identified in adrenal chromoffin granules. Immunohistochemical studies have demonstrated chromogranin A in most granule-containing endocrine cells, central and peripheral nerves, as well as in most neuroendoctrine tumors. This antibody reacts with human chromagranin A, but not with fragments located on the N-terminal half of the protein. Traces of antibodies to other human plasma proteins and human urine proteins have been removed by solid phase absorption. The antibody reacts with chromogranin A in neuroendocrine cells of the human stomach, colon, pancreas, adrenal gland, peripheral nerve tissue and carcinoid tumors.