Catalog Number | Size | Price | Availability |
IW-PA1010 | 9 ml | $258 | Yes |
Description
|
Aquaporin 1 is a 28-kD integral protein thought at first to
be a breakdown product of the Rh polypeptide but was later
shown to be a unique molecule that is abundant in
erythrocytes and renal tubules. AQP1 is also expressed by
the choroid plexus and various other tissues. It forms a
water-specific channel that provides the plasma membranes of
red cells and kidney proximal tubules with high permeability
to water, thereby permitting water to move in the direction
of an osmotic gradient. |
Catalog Number
|
IW-PA1010 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A synthetic peptide corresponding to a sequence mapping
near the C-terminal of human AQP1, identical to the related
mouse sequence.
|
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
Positive Control |
Kidney |
Cellular Localization |
Cytoplasmic |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C. Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval improves stain on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Suitable. |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1. Denker, B. M.; Smith, B. L.; Kuhajda, F. P.;
Agre, P. :
Identification, purification, and partial characterization
of a novel M(r) 28,000 integral membrane protein from
erythrocytes and renal tubules. J. Biol. Chem.
263: 15634-15642, 1988.
2.
Thiagarajah, J. R.; Verkman, A. S. :
Aquaporin deletion in mice reduces corneal water permeability and delays
restoration of transparency after swelling. J.
Biol. Chem. 277: 19139-19144, 2002.
|
Images |
Immunohistochemical analysis of formalin fixed paraffin-embedded
rat kidney tissue section using AQP1 antibody. Staining AQP1 in cytoplasm. DAB chromogenic reaction. |
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