Catalog Number | Size | Price | Availability |
IW-PA1224 | 9 ml | $258 | Yes |
Description
|
Core binding factor A1 (CBFA1/RUNX2) is a runt-like
transcription factor essential for osteoblast
differentiation.
This protein is a member of the RUNX family of transcription
factors and has a Runt DNA-binding domain. It is essential
for osteoblastic differentiation and skeletal morphogenesis
and acts as a scaffold for nucleic acids and regulatory
factors involved in skeletal gene expression.
D'Souza et al. (1999)
indicate a non-redundant role for Cbfa
|
Catalog Number
|
IW-PA1224 |
Quantity
|
9 ml |
Host
|
Rabbit
|
Clone
|
Polyclonal
|
Isotype
|
Rabbit IgG
|
Immunogen
|
A synthetic peptide corresponding to a sequence at the
C-terminal of human CBFA1, identical to the related rat and
mouse sequence.
|
Purity
|
Immunogen affinity purified
|
Conjugate
|
Unconjugated
|
Species Reactivity
|
Human, mouse, rat.
Not
tested in other species. |
Positive Control
|
Human
osteosarcoma
|
Cellular Localization
|
Cytoplasmic
|
Form
|
Ready to use solution. No further dilution needed. Serum blocking
step should be omitted.
|
Storage
|
Store at 2-8
°C. Do not freeze.
|
Applications
|
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested.
|
Limitations
|
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user.
|
Precautions
|
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes.
|
References
|
1.
Bergwitz, C.; Prochnau, A.; Mayr, B.; Kramer, F.-J.;
Rittierodt, M.; Berten, H.-L.; Hausamen, J.-E.; Brabant, G.
: Identification of
novel CBFA1/RUNX2 mutations causing cleidocranial dysplasia.
J. Inherit. Metab. Dis. 24: 648-656, 2001.
2. D'Souza, R.
N.; Aberg, T.; Gaikwad, J.; Cavender, A.; Owen, M.; Karsenty,
G.; Thesleff, I. :
Cbfa1 is required for epithelial-mesenchymal interactions regulating
tooth development in mice. Development 126:
2911-2920, 1999.
|
Images
|
Immunohistochemical analysis of formalin fixed paraffin embedded human bone sarcoma section using CBFA1/RUNX2 antibody.
|
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