Catalog Number | Size | Price | Availability |
IW-MA1015 | 9 ml | $258 | Yes |
Description
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The alpha-beta heterodimeric T-cell antigen receptor binds antigen in association with major histocompatibility complex proteins on host cell surfaces. These 2 disulfide-linked glycoproteins, TCRA and TCRB are associated on T-cell surfaces with a complex of proteins called CD3 (formerly T3). Human CD3 consists of at least 4 proteins: gamma, delta , epsilon, and zeta . The CD3-gamma/CD3-delta gene pair is within 300 kb of the CD3-epsilon gene and therefore these genes form a tightly linked cluster on 11q23. The clustering may be significant in terms of their simultaneous activations during T-cell development.
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Catalog Number
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IW-MA1015
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Quantity
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9 ml
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Host |
Mouse
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Clone |
CA-3
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Isotype |
Mouse IgG1
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Immunogen |
Human thymocytes followed by Sezary T cells.
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Purity |
Purified by the goat anti-mouse IgG affinity chromatography.
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Conjugate |
Unconjuated
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Species
Reactivity |
Human, rat. Not tested in other species.
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Positive
Control |
Human tonsil
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Cellular
Localization |
Membrane
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Form |
Ready to use solution in PBS based antibody dilution buffer containing 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted.
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Storage |
Store at 2-8 °C. Do not freeze.
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Applications |
IHC-P: Heat
induced epitope retrieval is required on formalin fixed
paraffin sections. IHC-Tek Epitope Retrieval Solution
(IW-1100) is recommended.
IHC-Fr:
Formalin fixed or acetone fixed frozen sections. ICC: Not tested.
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Limitations |
This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.
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Precautions |
Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.
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References |
1. Krissansen, G. W.; Owen, M.
J.; Verbi, W.; Crumpton, M. J. :
Primary structure
of the T3 gamma subunit of the T3/T cell antigen receptor
complex deduced from cDNA sequences: evolution of the T3
gamma and delta subunits.
EMBO J. 5: 1799-1808, 1986. 2. Tunnacliffe, A.; Buluwela, L.; Rabbitts, T. H. : Physical linkage of three CD3 genes on human chromosome 11. EMBO J. 6: 2953-2957, 1987.
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Images |
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