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CD40L IHC Antibody
Ready To Use
| Catalog Number | Size | Price | Availability |
| IW-PA1020 | 9 ml | $258 | Yes |
Description
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CD40 ligand(CD40L) is a type II membrane protein of 261
amino acids on activated T cells that induces B cell
proliferation and immunoglobulin secretion.
It has homology with tumour necrosis factor-alpha and
-beta, and has important functions in B-cell activation and
differentiation. Human CD40L with 5 exons, is mapped to the
proximal region of the mouse X chromosome on Xq26.3-27.1,
and can be detected on T cells but is absent from B cells
and monocytes. Since CD40L is expressed on platelets and
released from them on activation, its predictive value as a
marker for clinical outcome and the therapeutic effect of
inhibition of glycoprotein IIb /IIIa receptor in patients
with acute coronary syndromes was investigated. The soluble
CD40L may be involved in the process of restenosis and that
it exerts its effect by triggering a complex group of
inflammatory reactions on endothelial and mononuclear
cells.CD40L plays a central role in the pathophysiology of
acute coronary syndromes, and has a role in the pathogenesis
of coronary artery lesions.
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Catalog Number
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IW-PA1020 |
Quantity
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9 ml |
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Host
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Rabbit
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Clone
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Polyclonal
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Isotype
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IgG
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Immunogen
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A synthetic peptide corresponding to a sequence at the
N-terminal of
human CD40L , different from the relative sequence of mouse
by two amino acids.
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Purity
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Immunogen affinity purified
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Conjugate
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Unconjugated
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Species Reactivity
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Human, mouse, rat.
Not tested in other species. |
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Positive Control
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Human mammary cancer
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Cellular Localization
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Cytoplasmic
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Form
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Ready to use solution. No further dilution needed. Serum
blocking step should be omitted.
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Storage
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Store at 2-8
°C.
Do not freeze.
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Applications
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IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested. ICC: Suitable
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Limitations
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This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user.
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Precautions
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Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes.
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References
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1.Allen,R.C. et al. CD40 ligand gene defects responsible for
X-linked hyper-IgM syndrome. Science 259: 990-993, 1993. 2.Cipollone,F, et al. Preprocedural
level of soluble CD40L is predictive of enhanced
inflammatory response and restenosis after coronary
angioplasty. Circulation 108: 2776-2782, 2003.
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Images
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Immunohistochemical analysis of paraffin-embedded human
mammary cancer using CD40L antibody. Staining CD40L in
cytoplasm. DAB chromogenic reaction.
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