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CD54 (ICAM-1) IHC Antibody
Ready To Use
| Catalog Number | Size | Price | Availability |
| IW-PA1110 | 9 ml | $258 | Yes |
Description
|
CD54 also knows as ICAM-1. Intercellular adhesion molecule-1
(ICAM1) is a ligand for lymphocyte function-associated (LFA)
antigens. Intercellular adhesion molecule-1 (ICAM-1) is an
integral membrane protein, a member of the immunoglobulin
superfamily, and a ligand for LFA-1, a beta 2 leukocyte
integrin. ICAM1 protein is the major human rhinovirus
receptor. ICAM1 gene is mapped to human chromosome 19. In
humans, lymphocyte adhesion to cells is mediated by the
protein heterodimer CD11a/CD18 (Leu-CAMa, LFA-1) and its
ligand CD54 (ICAM-1). |
Catalog Number
|
IW-PA1110 |
Quantity
|
9 ml |
|
Host |
Rabbit |
|
Clone |
Polyclonal |
|
Isotype |
IgG |
|
Immunogen |
A peptide mapping at the C-terminal region of the human
ICAM-1, identical to the related rat and mouse sequence. |
|
Purity |
Immunogen affinity purified |
|
Conjugate |
Unconjugated |
|
Species Reactivity |
Human.
Not tested in other
species. |
|
Positive Control |
Human mammary cancer |
|
Cellular Localization |
Membrane/cytoplasmic |
|
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
|
Storage |
Store at 2-8
°C. Do not freeze. |
|
Applications |
IHC-P: Proteinase K pretreatment is required on
formalin fixed paraffin sections. IHC-Tek Proteinase K
Solution (Cat# IW-1101) is recommended.
IHC-Fr: Not tested.
ICC: Not tested. |
|
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
|
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
|
References |
1. Ballantyne, C. M.; Kozak, C.
A.; O'Brien, W. E.; Beaudet, A. L. :
Assignment of the
gene for intercellular adhesion molecule-1 (Icam-1) to
proximal mouse chromosome 9.
Genomics 9:
547-550, 1991.
2. Greve, J. M.; Davis, G.;
Meyer, A. M.; Forte, C. P.; Yost, S. C.; Marlor, C. W.;
Kamarck, M. E.; McClelland, A. :
The major human
rhinovirus receptor is ICAM-1.
Cell 56:
839-847, 1989.
3. Prieto, J.; Takei, F.;
Gendelman, R.; Christenson, B.; Biberfeld, P.; Patarroyo, M.
: MALA-2, mouse
homologue of human adhesion molecule ICAM-1 (CD54).
Europ. J. Immun.
19: 1551-1557, 1989. |
|
Images |
Immunohistochemical analysis of formalin fixed paraffin-embedded
human mammary cancer using CD54 antibody. Staining CD54 in cytoplasm. DAB chromogenic reaction.
|
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