Catalog Number | Size | Price | Availability |
IW-PA1128 | 9 ml | $258 | Yes |
Description
|
CRH is a 41-amino acid
peptide derived by enzymatic cleavage from a 191-amino acid
preprohormone and is located on
8q13. It is made not only in the hypothalamus but
also in peripheral tissues, such as T lymphocytes, and is
expressed in very large amounts in the human placenta. As a
placental clock, CRH controls the duration of pregnancy and
that the timing of the rise in CRH may permit prediction of
the onset of labor. Furthermore, CRH is the most proximal
element of the HPA axis, and it acts as a central
coordinator for neuroendocrine and behavioral responses to
stress. In addition, placental secretion of CRH is a marker
of the 'placental clock' that is active from an early stage
in human pregnancy and determines the length of gestation
and the timing of parturition and delivery.
|
Catalog Number
|
IW-PA1128 |
Quantity
|
9 ml |
Host
|
Rabbit
|
Clone
|
Polyclonal
|
Isotype
|
IgG
|
Immunogen
|
A synthetic peptide
mapping
at the N-terminal of human CRH, identical to the related rat
and mouse sequence.
|
Purity
|
Immunogen affinity
purified
|
Conjugate
|
Unconjugated
|
Species Reactivity
|
Human, mouse, rat.
Not tested
in other species. |
Positive Control
|
Brain (hypothalamus), placenta, thymus.
|
Cellular Localization
|
Secreted
|
Form
|
Ready to use
solution. No further dilution needed. Serum blocking step
should be omitted.
|
Storage
|
Store at 2-8
°C.
Do not freeze.
|
Applications
|
IHC-P: Heat induced
epitope retrieval is required on formalin fixed paraffin
sections.
IHC-Fr: Suitable.
ICC: Suitable.
|
Limitations
|
This product is intended
for Research Use Only. Interpretation of the test
results is solely the responsibility of the user.
|
Precautions
|
Users should follow
general laboratory precautions when handling this product.
Wear personal protective equipment to avoid contact with
skin and eyes.
|
References
|
1. Robinson, B. G.; Emanuel, R. L.;
Frim, D. M.; Majzoub, J. A. : Glucocorticoid stimulates
expression of corticotropin-releasing hormone gene in human
placenta. Proc. Nat. Acad. Sci. 85: 5244-5248, 1988.
2. Inder, W. J.; Prickett, T. C. R.;
Ellis, M. J.; Hull, L.; Reid, R.; Benny, P. S.; Livesey, J.
H.; Donald, R. A. : The utility of plasma CRH as a predictor
of preterm delivery. J. Clin. Endocr. Metab. 86: 5706-5710,
2001.
3. McLean, M.; Bisits,
A.; Davies, J.; Woods, R.; Lowry, P.; Smith, R. : A
placental clock controlling the length of human pregnancy.
Nature Med. 1: 460-463, 1995.
|
Images
|
Immunohistochemical
analysis of formalin fixed paraffin-embedded human
adenocarcinoma endometrium using CRH antibody.
|
Related Products