Catalog Number | Size | Price | Availability |
IW-PA1028 | 9 ml | $258 | Yes |
Description
|
C Reactive Protein (CRP)
is a major acute phase reactant synthesized primarily in the
liver hepatocytes. It is composed of 5 identical,
21,500-molecular weight subunits. CRP mediates activities
associated with preimmune nonspecific host resistance. CRP
shows the strongest association with cardiovascular events.
It is detectable on the surface of about 4% of normal
peripheral blood lymphocytes. Acute phase reactant CRP is
produced in the liver.
|
Catalog Number
|
IW-PA1028 |
Quantity
|
9 ml |
Host
|
Rabbit
|
Clone
|
Polyclonal
|
Isotype
|
IgG
|
Immunogen
|
A synthetic peptide
corresponding to a sequence at the N-terminal of human CRP,
identical to the related rat and mouse sequence.
|
Purity
|
Immunogen affinity
purified
|
Conjugate
|
Unconjugated
|
Species Reactivity
|
Human, mouse, rat.
Not tested
in other species. |
Positive Control
|
Liver, cardiac muscle
|
Cellular Localization
|
Cytoplasmic
|
Form
|
Ready to use
solution. No further dilution needed. Serum blocking step
should be omitted.
|
Storage
|
Store at 2-8
°C.
Do not freeze.
|
Applications
|
IHC-P: Heat induced
epitope retrieval enhance stain on formalin fixed paraffin
sections.
IHC-Fr: Not tested.
ICC: Not tested.
|
Limitations
|
This product is intended
for Research Use Only. Interpretation of the test
results is solely the responsibility of the user.
|
Precautions
|
Users should follow
general laboratory precautions when handling this product.
Wear personal protective equipment to avoid contact with
skin and eyes.
|
References
|
1.
Kilpatrick, J. M.; Volanakis, J.
E. : Molecular
genetics, structure, and function of C-reactive protein.
Immun. Res. 10: 43-53, 1991.
2.Kuta, A.
E.; Baum, L. L. :
C-reactive protein is produced by a small number of normal
human peripheral blood lymphocytes. J. Exp. Med.
164: 321-326, 1986.
3.Oliveira,
E. B.; Gotshlich, E. C.; Liu, T. :
Primary structure of
human C-reactive protein. J. Biol. Chem. 254:
489-502, 1979.
|
Images
|
Immunohistochemical analysis of formalin fixed paraffin-embedded rat cardiac muscle tissue using CRP antibody
Immunohistochemical staining of formalin fixed paraffin-embedded human liver using CRP antibody showing cytoplasmic staining pattern of hepatocytes.
|
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