CRP IHC Antibody

 

Ready To Use

 

Catalog Number Size Price Availability
IW-PA1028 9 ml $258 Yes

Description

C Reactive Protein (CRP) is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is composed of 5 identical, 21,500-molecular weight subunits. CRP mediates activities associated with preimmune nonspecific host resistance. CRP shows the strongest association with cardiovascular events. It is detectable on the surface of about 4% of normal peripheral blood lymphocytes. Acute phase reactant CRP is produced in the liver.

 

Catalog Number

 

IW-PA1028

Quantity

 

9 ml

Host

 

Rabbit

 

Clone

 

Polyclonal

 

Isotype

 

IgG

 

Immunogen

 

A synthetic peptide corresponding to a sequence at the N-terminal of human CRP, identical to the related rat and mouse sequence.

 

Purity

 

Immunogen affinity purified

 

Conjugate

 

Unconjugated

 

Species Reactivity

 

Human, mouse, rat. Not tested in other species.

Positive Control

 

Liver, cardiac muscle

 

Cellular Localization

 

Cytoplasmic

 

Form

 

Ready to use solution. No further dilution needed. Serum blocking step should be omitted.

 

Storage

 

Store at 2-8 °C. Do not freeze.

 

Applications

 

IHC-P: Heat induced epitope retrieval enhance stain on formalin fixed paraffin sections.

IHC-Fr: Not tested.

ICC: Not tested.

 

Limitations

 

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

 

Precautions

 

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

 

References

 

1. Kilpatrick, J. M.; Volanakis, J. E. : Molecular genetics, structure, and function of C-reactive protein. Immun. Res. 10: 43-53, 1991.

2.Kuta, A. E.; Baum, L. L. : C-reactive protein is produced by a small number of normal human peripheral blood lymphocytes. J. Exp. Med. 164: 321-326, 1986.

3.Oliveira, E. B.; Gotshlich, E. C.; Liu, T. : Primary structure of human C-reactive protein. J. Biol. Chem. 254: 489-502, 1979.

 

Images

 

Immunohistochemical analysis of formalin fixed paraffin-embedded rat cardiac muscle tissue using CRP antibody

 

Immunohistochemical staining of formalin fixed paraffin-embedded human liver using CRP antibody showing cytoplasmic staining pattern of hepatocytes.

 

Immunohistochemical staining of formalin fixed paraffin-embedded mouse embryo using CRP antibody

 

Immunohistochemical staining of formalin fixed paraffin-embedded rat liver using CRP antibody showing cytoplasmic staining pattern of hepatocytes. 

 

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