Catalog Number | Size | Price | Availability |
IW-PA1015 | 9 ml | $258 | Yes |
Description
|
Calbindin is a calcium-binding protein
belonging to the troponin C superfamily. Calretinin is
expressed in central and peripheral nervous system and in
many normal and pathological tissues. The rat and human
calretinin exhibit 98% sequence homology and 91% homology to
many other species. Two calcium binding proteins, calbindin
and calretinin, have been reported to be expressed in
abundance in Purkinje cells and other cell types in the
cerebellum. |
Catalog Number
|
IW-PA1015 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A synthetic peptide corresponding to a sequence at the
N-terminal of human calretinin, identical to the related rat
sequence. |
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
Positive Control |
Brain, human mammary cancer. |
Cellular Localization |
Cytoplasmic |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C. Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested. |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1. Parmentier M.; "The human calbindins: cDNA and gene
cloning.";Adv. Exp. Med. Biol. 255:233-240(1989).
2. Strauss K.I., Kuznicki J., Winsky L., Kawagoe J.I.,
Hammer M., Jacobowitz D.M.;"The mouse calretinin gene
promoter region: structural and functional
components.";Brain Res. Mol. Brain Res. 49:175-187(1997).
3. Gabrielides C., McCormack A.L., Hunt D.F., Christakos
S.;"Brain calbindin-D28k and an Mr 29,000 calcium binding
protein in cerebellum are different but related proteins:
evidence obtained from sequence analysis by tandem mass
spectrometry.";Biochemistry 30:656-662(1991). |
Images |
Immunohistochemical analysis of formalin fixed paraffin-embedded
human mammary cancer
using Calretinin antibody
Immunohistochemistry
|
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