Catalog Number | Size | Price | Availability |
IW-PA1113 | 9 ml | $258 | Yes |
Description
|
Caspase-2, which is involved in
stress-induced apoptosis, is recruited into a large protein
complex, the molecular composition of which remains elusive.
activation of caspase-2 occurs in a complex that contains
the death domain-containing protein PIDD, whose expression
is induced by p53, and the adaptor protein RAIDD. Increased
PIDD expression resulted in spontaneous activation of
caspase-2 and sensitization to apoptosis by genotoxic
stimuli. Caspase-2 acts both as a positive and negative cell
death effector, depending upon cell lineage and stage of
development. |
Catalog Number
|
IW-PA1113 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A synthetic peptide mapping
at the C-terminal of human Caspase-2, identical to the
related rat sequence. |
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Human, rat.
Not tested in
other species. |
Positive Control |
Spleen, intestine, testis, lymph node. |
Cellular Localization |
Cytoplasmic |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C. Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested. |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1.Bergeron, L.; Perez, G. I.; Macdonald, G.;
Shi, L.; Sun, Y.; Jurisicova, A.; Varmuza, S.; Latham, K.
E.; Flaws, J. A.; Salter, J. C. M.; Hara, H.; Moskowitz, M.
A.; Li, E.; Greenberg, A.; Tilly, J. L.; Yuan, J. :
Defects in
regulation of apoptosis in caspase-2-deficient mice.
Genes Dev. 12: 1304-1314, 1998.
2.Tinel, A.; Tschopp, J. :
The PIDDosome, a
protein complex implicated in activation of caspase-2 in
response to genotoxic stress. Science
304: 843-846, 2004.
|
Images |
Immunohistochemical analysis of paraffin-embedded sections. Rat spleen tissue using Caspase-2 antibody
Immunohistochemical analysis of paraffin-embedded sections
Immunohistochemical analysis of paraffin-embedded
human mammary cancer tissue sections using Caspase-2 antibody |
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