Catalog Number | Size | Price | Availability |
IW-PA1117 | 9 ml | $258 | Yes |
Description
|
Catenin γ, also known as junction plakoglobin (JUN) or
plakoglobin (PKGB). Plakoglobin is a major cytoplasmic
protein which is the only known constituent common to
submembranous plaques of both desmosomes and intermediate
junctions. Cateninβ and cateninγ (plakoglobin), vertebrate
homologs of Drosophila armadillo, function in cell adhesion
and the Wnt signaling pathway. Cateninγ may have distinct
roles in Wnt signaling and cancer via differential effects
on downstream target genes.
|
Catalog Number
|
IW-PA1117 |
Quantity
|
9 ml |
Host
|
Rabbit
|
Clone
|
Polyclonal
|
Isotype
|
IgG
|
Immunogen
|
A synthetic peptide
corresponding to a sequence at the N-terminal of human
Catenin γ,
identical to the related mouse and rat sequence.
|
Purity
|
Immunogen affinity
purified
|
Conjugate
|
Unconjugated
|
Species Reactivity
|
Human, mouse, rat.
Not tested
in other species. |
Positive Control
|
Human mammary cancer |
Cellular Localization
|
Cytoplasmic
|
Form
|
Ready to use
solution. No further dilution needed. Serum blocking step
should be omitted.
|
Storage
|
Store at 2-8
°C.
Do not freeze.
|
Applications
|
IHC-P: Heat induced
epitope retrieval is required on formalin fixed paraffin
sections.
IHC-Fr: Not tested.
ICC: Suitable.
|
Limitations
|
This product is intended
for Research Use Only. Interpretation of the test
results is solely the responsibility of the user.
|
Precautions
|
Users should follow
general laboratory precautions when handling this product.
Wear personal protective equipment to avoid contact with
skin and eyes.
|
References
|
1.
Kolligs, F. T.; Kolligs, B.; Hajra,
K. M.; Hu, G.; Tani, M.; Cho, K. R.; Fearon, E. R. :
Gamma-catenin is
regulated by the APC tumor suppressor and its oncogenic
activity is distinct from that of beta-catenin.
Genes Dev. 14: 1319-1331, 2000.
|
Images
|
Immunohistochemical
analysis of formalin fixed paraffin-embedded human mammary cancer
using Catenin γ antibody. Staining Catenin γ in
cytoplasm. DAB chromogenic reaction.
|
Related Products