Catalog Number | Size | Price | Availability |
IW-MA1036 | 9 ml | $258 | 1-2 weeks |
Description
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Desmin belongs to the type III family of intermediate filaments, a class of cytoskeletal elements. DES gene encodes desmin, a muscle-specific cytoskeletal protein found in smooth, cardiac, and heart muscles. Tidball (1992) found that desmin was codistributed with actin thin filaments within the cellular processes of myotendinous junctions in frog skeletal muscle. DES gene contains 9 exons and spans about 8.4 kb. By in situ hybridization, Viegas-Pequignot et al. (1989) localized the gene to 2q35. Desmin mutation responsible for idiopathic dilated cardiomyopathy.
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Catalog Number
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IW-MA1036
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Quantity
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9 ml
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Host |
Mouse
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Clone |
DES-82
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Isotype |
Mouse IgG1
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Immunogen |
Desmin from pig stomach.
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Purity |
Purified by the goat anti-mouse IgG affinity chromatography
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Conjugate |
Unconjugated
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Species
Reactivity |
Human, mouse, rat. Not tested in other species.
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Positive
Control |
Skeletal muscle, cardiac tissue.
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Cellular
Localization |
Cytoplasmic
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Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted.
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Storage |
Store at 2-8 °C. Do not freeze.
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Applications |
IHC-P: Heat
induced epitope retrieval is required on formalin fixed
paraffin sections.
IHC-Fr: Not
tested. ICC: Not tested.
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Limitations |
This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.
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Precautions |
Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.
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References |
1. Tidball, J. G. :
Desmin at myotendinous junctions.
Exp. Cell Res.
199: 206-212, 1992.
2. Viegas-Pequignot, E.; Lin, L. Z.; Dutrillaux, B.; Apiou,
F.; Paulin, D. :
Assignment of human desmin gene to band 2q35 by
nonradioactive in situ hybridization.
Hum. Genet.
83: 33-36, 1989. 3. Li, D.; Tapscoft, T.; Gonzalez, O.; Burch, P. E.; Quinones, M. A.; Zoghbi, W. A.; Hill, R.; Bachinski, L. L.; Mann, D. L.; Roberts, R. : Desmin mutation responsible for idiopathic dilated cardiomyopathy. Circulation 100: 461-464, 1999.
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Images |
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