Catalog Number | Size | Price | Availability |
IW-MA1038 | 9 ml | $258 | Yes |
Description
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Elastin is a major structural protein of tissues such as aorta, which must expand rapidly and recover completely. Elastin chains are cross-linked together into an extensible 3D network. It is a molecular determinant of late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in elastin are a cause of autosomal dominant cutis laxa.
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Catalog Number
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IW-MA1038
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Quantity
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9 ml
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Host |
Mouse
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Clone |
IL-4
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Isotype |
Mouse IgG1
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Immunogen |
Bovine α-elastin.
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Purity |
Purified by the goat anti-mouse IgG affinity chromatography
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Conjugate |
Unconjugated
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Species Reactivity |
Human, dog, guinea pig. Not tested in other species.
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Positive Control |
Skin, kidney, small intestine.
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Cellular
Localization |
Extracellular
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Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted.
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Storage |
Store at 2-8 °C. Do not freeze.
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Applications |
IHC-P:
Proteolytic Induced
Epitope Retrieval (PIER) (Proteinase K)
required on formalin fixed paraffin embedded tissue
sections.
IHC-Fr: Not
tested. ICC: Not tested.
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Limitations |
This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.
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Precautions |
Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.
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References |
1. Rosenbloom, J. : Personal Communication. Philadelphia,
Pa., 4/1984.
2. Urban, Z.; Riazi, S.; Seidl, T. L.; Katahira, J.; Smoot,
L. B.; Chitayat, D.; Boyd, C. D.; Hinek, A. :
Connection between
elastin haploinsufficiency and increased cell proliferation
in patients with supravalvular aortic stenosis and Williams-Beuren
syndrome. Am. J. Hum. Genet. 71: 30-44, 2002. 3. Uitto, J.; Christiano, A. M.; Kahari, V.-M.; Bashir, M. M.; Rosenbloom, J. : Molecular biology and pathology of human elastin. Biochem. Soc. Trans. 19: 824-829, 1991.
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Images |
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