Catalog Number | Size | Price | Availability |
IW-PA1119 | 9 ml | $258 | Yes |
Description
|
FAS (also known as surface antigen APO1 or CD95) is a
member of the tumour-necrosis receptor factor family of
death receptors, can induce apoptosis or, conversely, can
deliver growth stimulatory signals. It acts as an inducer of
both neurite growth in vitro and accelerated recovery after
nerve injury in vivo. Fas antigen is expressed and
functional on papillary thyroid cancer cells and this may
have potential therapeutic significance. The FAS antigen
shows structural homology with a number of cell surface
receptors, including tumor necrosis factor (TNF) receptors
and the low-affinity nerve growth factor receptor (NGFR) and
is mapped to 10q24.1. And the FAS and FASL system plays a
key role in regulating apoptotic cell death and corruption
of this signaling pathway has been shown to participate in
immune escape and tumorigenesis. |
Catalog Number
|
IW-PA1119 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A synthetic peptide corresponding to a sequence at the
N-terminal of rat FAS, different from the related mouse
sequence by seven amino acids. |
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Mouse, rat.
Not tested in
other species. |
Positive Control |
Spleen, Hela cells. |
Cellular Localization |
Cytoplasmic |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C. Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval enhance stain on
formalin fixed paraffin sections.
IHC-Fr: Formalin or acetone fixed tissues.
ICC: Suitable. |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1. Desbarats, J.; Birge, R. B.;
Mimouni-Rongy, M.; Weinstein, D. E.; Palerme, J.-S.; Newell,
M. K. : Fas
engagement induces neurite growth through ERK activation and
p35 upregulation. Nature Cell Biol. 5:
118-125, 2003.
2. Arscott, P. L.; Stokes, T.;
Myc, A.; Giordano, T. J.; Thompson, N. W.; Baker, J. R., Jr.
: Fas (CD95)
expression is up-regulated on papillary thyroid carcinoma.
J. Clin. Endocr. Metab. 84: 4246-4252, 1999.
3. Zhang, X.; Miao, X.; Sun, T.;
Tan, W.; Qu, S.; Xiong, P.; Zhou, Y.; Lin, D. :
Functional polymorphisms in cell death pathway genes FAS and FASL
contribute to the risk of lung cancer. J. Med.
Genet. 42: 479-484, 2005. |
Images |
Immunohistochemical analysis of Hela cell. Staining FAS in cytoplasm by SABC-Cy3.
Immunohistochemical analysis of frozen rat spleen tissue
section using FAS antibody.
Immunohistochemical analysis of formalin fixed paraffin-embedded
rat spleen tissue section using FAS antibody.
Immunohistochemical analysis of formalin fixed paraffin-embedded
mouse spleen tissue section using FAS antibody. |
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