Catalog Number | Size | Price | Availability |
IW-PA1034 | 9 ml | $258 | Yes |
Description
|
Irmler et al. (1997) isolated human cDNAs
encoding 2 isoforms of FLIP. FLIP(L), the longer isoform,
contains 2 DEDs and a caspase-like domain, and FLIP(S), the
shorter isoform, contains only the 2 DEDs followed by a
C-terminal extension of approximately 50 amino acids. High
levels of FLIP (L) protein were detected in melanoma cell
lines and malignant melanoma tumors. FLIP may be implicated
in tissue homeostasis as an important regulator of apoptosis
|
Catalog Number
|
IW-PA1034 |
Quantity
|
9 ml |
Host
|
Rabbit
|
Clone
|
Polyclonal
|
Isotype
|
IgG
|
Immunogen
|
A synthetic peptide corresponding to a sequence mapping at
the C-terminal of human FLIP-L, identical to the related
mouse sequence.
|
Purity
|
Immunogen affinity purified
|
Conjugate
|
Unconjugated
|
Species Reactivity
|
Human, mouse, rat.
Not tested in other species. |
Positive Control
|
Human Mammary cancer
|
Cellular Localization
|
Cytoplasmic
|
Form
|
Ready to use solution. No further dilution needed. Serum blocking
step should be omitted.
|
Storage
|
Store at 2-8
°C. Do not freeze.
|
Applications
|
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested.
|
Limitations
|
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user.
|
Precautions
|
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes.
|
References
|
Irmler, M.; Thome, M.; Hahne, M.; Schneider, P.; Hofmann, K.;
Steiner, V.; Bodmer, J.-L.; Schroter, M.; Burns, K.;
Mattmann, C.; Rimoldi, D.; French, L. E.; Tschopp, J. :
Inhibition of death
receptor signals by cellular FLIP. Nature 388:
190-195, 1997.
|
Images
|
Immunohistochemical analysis of formalin fixed
paraffin-embedded human mammary cancer
using FLIPL
antibody
|
Related Products