Catalog Number | Size | Price | Availability |
IW-PA1104 | 9 ml | $258 | Yes |
Description
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The forkhead transcription factor gene, FOXL2 located in
blepharophimosis-ptosis-epicanthus inversus syndrome (BPES)
critical region on chromosome 3q23. Consistent with an
involvement in BPES, FOXL2 is selectively expressed in the
mesenchyme of developing mouse eyelids and in adult ovarian
follicles; in adult humans, it appears predominantly in the
ovary. FOXL2 haploinsufficiency may cause BPES types I and
II by the effect of a null allele and a hypomorphic allele,
respectively. Furthermore, in a fraction of the BPES
patients the genetic defect does not reside within the
coding region of the FOXL2 gene and may be caused by a
position effect. FOXL2 mutations can also cause gonadal
dysgenesis or premature ovarian failure (POF) in women, as
well as eyelid/forehead dysmorphology in both sexes.
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Catalog Number
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IW-PA1104 |
Quantity
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9 ml |
Host
|
Rabbit
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Clone
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Polyclonal
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Isotype
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IgG
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Immunogen
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A synthetic peptide corresponding to a sequence at the
N-terminal of human FOXL2, identical to the related rat and
mouse sequence.
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Purity
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Immunogen affinity purified
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Conjugate
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Unconjugated
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Species Reactivity
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Human, mouse, rat.
Not tested in other species. |
Positive Control
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Ovary, human ovary cancer
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Cellular Localization
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Cytoplasmic
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Form
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Ready to use solution. No further dilution needed. Serum
blocking step should be omitted.
|
Storage
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Store at 2-8
°C.
Do not freeze.
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Applications
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IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Suitable.
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Limitations
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This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user.
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Precautions
|
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes.
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References
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1.
Crisponi, L.; Deiana, M.; Loi, A.; Chiappe, F.; Uda, M.;
Amati, P.; Bisceglia, L.; Zelante, L.; Nagaraja, R.; Porcu,
S.; Ristaldi, M. S.; Marzella, R.; and 10 others :
The putative
forkhead transcription factor FOXL2 is mutated in
blepharophimosis/ptosis/epicanthus inversus syndrome.
Nature Genet. 27: 159-166, 2001.
2.
De Baere, E.; Dixon, M. J.; Small, K. W.; Jabs, E. W.;
Leroy, B. P.; Devriendt, K.; Gillerot, Y.; Mortier, G.;
Meire, F.; Van Maldergem, L.; Courtens, W.; Hjalgrim, H.;
and 15 others :
Spectrum of FOXL2 gene mutations in
blepharophimosis-ptosis-epicanthus inversus (BPES) families
demonstrates a genotype-phenotype correlation.
Hum. Molec. Genet. 10: 1591-1600, 2001.
3.
Uda, M.; Ottolenghi, C.; Crisponi, L.; Garcia, J. E.; Deiana,
M.; Kimber, W.; Forabosco, A.; Cao, A.; Schlessinger, D.;
Pilia, G. : Foxl2
disruption causes mouse ovarian failure by pervasive
blockage of follicle development. Hum. Molec.
Genet. 13: 1171-1181, 2004.
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Images
|
Immunohistochemical analysis of formalin fixed paraffin-embedded rat ovary tissue section using FoxL2 antibody showing cytoplasmic staining.
Immunohistochemical analysis of formalin fixed
paraffin-embedded human ovarian cancer using FoxL2 antibody
showing cytoplasmic staining.
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