Catalog Number | Size | Price | Availability |
IW-PA1120 | 9 ml | $258 | Yes |
Description
|
GLUT1,also known as SLC2A1, is a major glucose transporter
in the mammalian blood-brain barrier whose gene is mapped to
1p35-p31.3 and contains 10 exons. It is present at high
levels in primate erythrocytes and brain endothelial cells.
Not only can transport dehydroascorbic acid (the oxidized
form of vitamin C) into the brain1, GLUT1 is also
likely to contribute to HTLV-associated disorders through
interacting with HTLV envelope glycoproteins2.
Functionally,
GLUT1 deficiency causes a decrease in embryonic glucose
uptake and apoptosis, which may be involved in diabetic
embryopathy3, by contrast, an increased
expression of GLUT1 in some malignant tumors may suggest a
role for glucose-derivative tracers to detect in vivo
thyroid cancer metastases by positron-emission tomography
scanning.
|
Catalog Number
|
IW-PA1120 |
Quantity
|
9 ml |
Host
|
Rabbit
|
Clone
|
Polyclonal
|
Isotype
|
IgG
|
Immunogen
|
A peptide mapping very near
the N-terminal end
of GAD67
of human origin, identical to the related mouse sequence.
|
Purity
|
Immunogen affinity purified
|
Conjugate
|
Unconjugated
|
Species Reactivity
|
Human, mouse, rat.
Not tested in other species. |
Positive Control
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Cardiac muscle, human adenocarcinoma endometrium.
|
Cellular Localization
|
Cytoplasmic
|
Form
|
Ready to use solution. No further dilution needed. Serum
blocking step should be omitted.
|
Storage
|
Store at 2-8
°C.
Do not freeze.
|
Applications
|
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Suitable.
|
Limitations
|
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user.
|
Precautions
|
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes.
|
References
|
1.Agus, D. B.; Gambhir, S. S.; Pardridge, W. M.; Spielholz,
C.; Baselga, J.; Vera, J. C.; Golde, D. W. : Vitamin C
crosses the blood-brain barrier in the oxidized form through
the glucose transporters. J. Clin. Invest. 100: 2842-2848,
1997.
2.Manel, N.; Kim, F. J.; Kinet, S.; Taylor, N.; Sitbon, M.;
Battini, J.-L. : The ubiquitous glucose transporter GLUT-1
is a receptor for HTLV. Cell 115: 449-459, 2003.
3.Heilig, C. W.; Saunders, T.; Brosius, F. C., III; Moley,
K.; Heilig, K.; Baggs, R.; Guo, L.; Conner, D. : Glucose
transporter-1-deficient mice exhibit impaired development
and deformities that are similar to diabetic embryopathy.
Proc. Nat. Acad. Sci. 100: 15613-15618, 2003.
4.Lazar, V.; Bidart, J.-M.; Caillou, B.; Mahe, C.; Lacroix,
L.; Filetti, S.; Schlumberger, M. : Expression of the
Na(+)/I(-) symporter gene in human thyroid tumors: a
comparison study with other thyroid-specific genes. J. Clin.
Endocr. Metab. 84: 3228-3234, 1999.
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Images
|
Immunohistochemical analysis of formalin fixed
paraffin-embedded rat cardiac muscle using Glut1 antibody
Immunohistochemical analysis of formalin fixed
paraffin-embedded human adenocarcinoma endometrium using
Glut1 antibody
|
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