Catalog Number | Size | Price | Availability |
IW-PA1039 | 9 ml | $258 | Yes |
Description
|
Facilitated glucose transport by mammalian cells is not a
property of a single protein but an activity associated with
a family of structurally related proteins. Glucose
transporter 4 is a insulin-responsive glucose transporter .
It belongs to solute carrier family 2,member 1. Insulin
alters the subcellular localization of GLUT4 vesicles in
human muscle, and that this effect is impaired equally in
insulin-resistant subjects with and without diabetes. A
similar pattern of defects cause insulin resistance in human
adipocytes.Human insulin resistance involves a defect in
GLUT4 traffic and targeting leading to accumulation in a
dense membrane compartment from which insulin is unable to
recruit GLUT4 to the cell surface.
|
Catalog Number
|
IW-PA1039 |
Quantity
|
9 ml |
Host
|
Rabbit
|
Clone
|
Polyclonal
|
Isotype
|
IgG
|
Immunogen
|
A synthetic peptide corresponding to the C-terminal of human
glucose transporter 4, identical to the related rat and
mouse sequence.
|
Purity
|
Immunogen affinity purified
|
Conjugate
|
Unconjugated
|
Species Reactivity
|
Human, mouse, rat.
Not
tested in other species. |
Positive Control
|
Ovary cancer
|
Cellular Localization
|
Cytoplasmic
|
Form
|
Ready to use solution. No further dilution needed. Serum blocking
step should be omitted.
|
Storage
|
Store at 2-8
°C. Do not freeze.
|
Applications
|
IHC-P: Heat induced epitope retrieval improve stain on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested.
|
Limitations
|
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user.
|
Precautions
|
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes.
|
References
|
1. Birnbaum, M. J. :
Identification of a novel gene encoding an insulin-responsive glucose
transporter protein. Cell 57: 305-315, 1989.
2. Bell, G. I.; Kayano, T.; Buse,
J. B.; Burant, C. F.; Takeda, J.; Lin, D.; Fukumoto, H.;
Seino, S. : Molecular biology of mammalian glucose transporters. Diabetes
Care 13: 198-208, 1990.
3. Garvey, W. T.; Maianu, L.; Zhu,
J.-H.; Brechtel-Hook, G.; Wallace, P.; Baron, A. D. :
Evidence for defects in the trafficking and translocation of GLUT4
glucose transporters in skeletal muscle as a cause of human
insulin resistance. J. Clin. Invest. 101:
2377-2386, 1998.
|
Images
|
Immunohistochemical analysis of formalin fixed paraffin-embedded
human ovary cancer using
GLUT4 antibody
|
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