GR IHC Antibody


Ready To Use


Catalog Number Size Price Availability
IW-PA1107 9 ml $258 Yes


Glucocorticoid receptor (GR) maps to the distal long arm of chromosome 5. The human glucocorticoid receptor (hGR) gene contains a total of 10 exons and has a minimum size of 80 kilobases. The identification of complementary DNAs encoding the human glucocorticoid receptor (hGR) predicts two protein forms (alpha and beta; 777 and 742 amino acids long, respectively) which differ at their carboxy termini and both forms of the receptor are related, with respect to their domain structure, to the v-erb-A oncogene product of avian  erythroblastosis virus (AEV), which suggests that steroid receptor genes and the c-erb-A proto-oncogene are derived from a common primordial regulatory gene. Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment.


Catalog Number





9 ml











Rabbit IgG




A synthetic peptide corresponding to a sequence at the C-terminal of

human GR, identical to the related rat and mouse sequence.




Immunogen affinity purified






Species Reactivity


Human, mouse, rat. Not tested in other species.

Positive Control


Human mammary cancer

Cellular Localization






Ready to use solution. No further dilution needed. Serum blocking step should be omitted.




Store at 2-8 °C. Do not freeze.




IHC-P: Formalin fixed paraffin embedded tissue sections.

IHC-Fr: Suitable.

ICC: Not tested.




This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.




Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.




1. Encio, I. J.; Detera-Wadleigh, S. D. : The genomic structure of the human glucocorticoid receptor. J. Biol. Chem. 266: 7182-7188, 1991.

2. Weinberger, C.; Hollenberg, S. M.; Rosenfeld, M. G.; Evans, R. M. : Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product. Nature 318: 670-672, 1985.

3. Bledsoe, R. K.; Montana, V. G.; Stanley, T. B.; Delves, C. J.; Apolito, C. J.; McKee, D. D.; Consler, T. G.; Parks, D. J.; Stewart, E. L.; Willson, T. M.; Lambert, M. H.; Moore, J. T.; Pearce, K. H.; Xu, H. E.: Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition. Cell 110: 93-105, 2002.




Immunohistochemical analysis of formalin fixed paraffin-embedded human mammary cancer tissue section using GR antibody showing nuclear staining.



 Related Products