Catalog Number | Size | Price | Availability |
IW-PA1040 | 9 ml | $258 | Yes |
Description
|
Glutathione S-transferases pi, also known as GST3, present
in all tissues and cells, with the exception of red cells,
in which only erythrocyte GST (GSTe) is observed. The GST-pi
gene has 7 exons and 6 introns contained within
approximately 2.8 kilobases. The GST-pi gene is mapped to
chromosome 11 .Placental
glutathione-S-transferase-pi mRNA is abundantly expressed in
human skin. GSTP does not contribute in vivo to the
formation of glutathione conjugates of acetaminophen but
plays a novel and unexpected role in the toxicity of this
compound.
|
Catalog Number
|
IW-PA1040 |
Quantity
|
9 ml |
Host
|
Rabbit
|
Clone
|
Polyclonal
|
Isotype
|
Rabbit IgG
|
Immunogen
|
A peptide mapping at the C-terminus of
GSTpi of human origin,different from the related
mouse sequence by two sequence.
|
Purity
|
Immunogen affinity purified
|
Conjugate
|
Unconjugated
|
Species Reactivity
|
Human, mouse, rat.
Not
tested in other species. |
Positive Control
|
Endometrial Carcinoma |
Cellular Localization
|
Cytoplasmic
|
Form
|
Ready to use solution. No further dilution needed. Serum blocking
step should be omitted.
|
Storage
|
Store at 2-8
°C. Do not freeze.
|
Applications
|
IHC-P: Formalin fixed paraffin embedded tissue sections.
IHC-Fr: Acetone fixed frozen sections.
ICC: Acetone fixed cultured cells.
|
Limitations
|
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user.
|
Precautions
|
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes.
|
References
|
[1]. Morrow, C. S.; Cowan, K.
H.; Goldsmith, M. E. :
Structure of the
human genomic glutathione S-transferase-pi gene.
Gene 75: 3-11, 1989
2. Islam, M. Q.; Platz, A.; Szpirer, J.; Szpirer, C.; Levan,
G.; Mannervik, B. :
Chromosomal localization of human glutathione transferase
genes of classes alpha, mu and pi. Hum. Genet.
82: 338-342, 1989.
3. Konohana, A.; Konohana, I.;
Schroeder, W. T.; O'Brien, W. R.; Amagai, M.; Greer, J.;
Shimizu, N.; Gammon, W. R.; Siciliano, M. J.; Duvic, M. :Placental
glutathione-S-transferase-pi mRNA is abundantly expressed in
human skin. J. Invest. Derm. 95: 119-126, 199.
|
Images
|
Immunohistochemical analysis of formalin fixed
paraffin-embedded human
endometrial carcinoma
using
GSTpi antibody
|
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