Description

Glucagon is a member of a multigene family that includes secretin. Glucagon is a 29-amino acid pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. the human glucagon gene is approximately 9.4 kb long and contains 6 exons and 5 introns, and assigned to 2q36-2q37.

Catalog Number

IW-MA1047

Quantity

9 ml

Host

Mouse

Clone

IMD-7

Isotype

Mouse IgG1

Immunogen

Polymerized porcine glucagon.

Purity

Purified by the goat anti-mouse IgG affinity chromatography.

Conjugate

Unconjugated

Species Reactivity

Human, rat. Not tested in other species.

Positive Control

Pancreas.

Cellular Localization

Cytoplasmic

Form

Ready to use solution. No further dilution needed. Serum blocking step should be omitted.

Storage

Store at 2-8 °C. Do not freeze.

Applications

IHC-P: Formalin fixed paraffin embedded tissue sections.

IHC-Fr: Not tested.

ICC: Not tested.

Limitations

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

Precautions

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

References

1. Schroeder, W. T.; Lopez, L. C.; Harper, M. E.; Saunders, G. F. : Localization of the human glucagon gene (GCG) to chromosome segment 2q36-37. Cytogenet. Cell Genet. 38: 76-79, 1984.

2. White, J. W.; Saunders, G. F. : Structure of the human glucagon gene. Nucleic Acids Res. 14: 4719-4730, 1986.

Images

Immunohistochemistry staining of formalin fixed paraffin-embedded rat pancreas section using Glucagon antibody showing cytoplasmic staining.