Catalog Number | Size | Price | Availability |
IW-PA1112 | 9 ml | $258 | Yes |
Description
|
Interferon-induced Transmembrane Protein 1 (IFITM1), also
called Interferon-induced Protein 17 (IFI17). IFITM1
activity is required for primordial germ cells (PGCs)
transit from the mesoderm into the endoderm, and that it
appears to act via a repulsive mechanism, such that PGCs
avoid Ifitm1-expressing tissues. It is mapped to
Chr.11 and belongs to the family of
interferon-induced transmembrane proteins (Ifitm/mil/fragilis),
which encodes cell surface proteins that may modulate cell
adhesion and influence cell differentiation.
Interferon-inducible membrane proteins of approximately 17
kDa have been suggested to play a role in the
antiproliferative activity of interferons based on their
pattern of induction in interferon-sensitive and -resistant
cell lines and the ability of a membrane fraction enriched
in 17-kDa proteins to inhibit cell growth.
|
Catalog Number
|
IW-PA1112 |
Quantity
|
9 ml |
Host
|
Rabbit
|
Clone
|
Polyclonal
|
Isotype
|
Rabbit IgG
|
Immunogen
|
A synthetic peptide corresponding to a sequence at the
N-terminal of human IFITM1, identical to the related rat and
mouse sequence.
|
Purity
|
Immunogen affinity purified
|
Conjugate
|
Unconjugated
|
Species Reactivity
|
Human.
Not tested in other species. |
Positive Control
|
Human intestine cancer, mammary cancer. |
Cellular Localization
|
Cytoplasmic
|
Form
|
Ready to use solution. No further dilution needed. Serum
blocking step should be omitted.
|
Storage
|
Store at 2-8
°C.
Do not freeze.
|
Applications
|
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin embedded tissue sections.
IHC-Fr: Suitable.
ICC: Not tested
|
Limitations
|
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user.
|
Precautions
|
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes.
|
References
|
1.
Tanaka, S. S.; Yamaguchi, Y. L.; Tsoi, B.; Lickert, H.; Tam,
P. P. L. :
IFITM/Mil/Fragilis family proteins IFITM1 and IFITM3 play
distinct roles in mouse primordial germ cell homing and
repulsion. Dev. Cell 9: 745-756, 2005.
2. Deblandre, G. A.; Marinx, O.
P.; Evans. S. S.; Majjaj, S.; Leo, O.; Caput, D.; Huez, G.
A.; Wathelet, M. G. :
Expression cloning
of an interferon-inducible 17-kDa membrane protein
implicated in the control of cell growth. J. Biol.
Chem. 270: 23860-23866, 1995.
|
Images
|
Immunohistochemical
analysis of formalin fixed paraffin-embedded human mammary
cancer using IFITM1 antibody showing cytoplasmic staining.
|
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