Catalog Number | Size | Price | Availability |
IW-PA1045 | 9 ml | $258 | Yes |
Description
|
Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1)
chain to form a heterodimer that functions as a dual laminin/collagen
receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half,
followed by 3 divalent cation-binding sites and a C-terminal
transmembrane domain with a short cytoplasmic tail. It also
has 28 potential N-glycosylation sites. Human ITGA1 was
expressed in a mouse fibroblast cell line as a 180-kD
protein. ITGA1 is involved in the early remodeling of
osteoarthritic cartilage and plays an essential role in the
regulation of mesenchymal stem cell proliferation and
cartilage production.
It also plays an essential role in the regulation of
MSC proliferation and cartilage production. |
Catalog Number
|
IW-PA1045 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A peptide at the C-terminus of ITGA1 of human origin,
identical to the related mouse sequence. |
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
Positive Control |
Human pelvic cavity cancer |
Cellular Localization |
Cytoplasmic |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C. Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested. |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1. Douville, P.; Seldin, M. F.; Carbonetto, S. : Genetic
mapping of the integrin alpha-1 gene (Vla1) to mouse
chromosome 13. Genomics 14: 503-505, 1992.
2. Lee HJ, Kim SY; Koh JM; Bok J; Kim KJ; Kim KS; Park MH;
Shin HD; Park BL; Kim TH; Hong JM; Park EK; Kim DJ; Oh B;
Kimm K; Kim GS; Lee JY. Polymorphisms and haplotypes of
integrinalpha1 (ITGA1) are associated with bone mineral
density and fracture risk in postmenopausal Koreans.Bone.
2007 Dec;41(6):979-86. Epub 2007 Sep 5.
3. Ekholm, E.; Hankenson, K. D.; Uusitalo, H.; Hiltunen,
A.; Gardner, H.; Heino, J.; Penttinen, R. : Diminished
callus size and cartilage synthesis in alpha-1 beta-1
integrin-deficient mice during bone fracture healing. Am. J.
Path. 160: 1779-1785, 2002. |
Images |
Immunohistochemical analysis of paraffin-embedded sections
Human pelvic cavity cancer
using
ITGA1
antibody |
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