Catalog Number | Size | Price | Availability |
IW-PA1046 | 9 ml | $258 | Yes |
Description
|
The integrin family includes cell surface receptors for
extracellular matrix components as well as receptors
involved in various aspects of leukocyte adhesion. Integrin
alpha chain 4 (ITGA4) is assigned to 2q31-q32.
Interaction between
leukemic-cell VLA-4 and stromal fibronectin is a decisive
factor for minimal residual disease of acute myelogenous
leukemia. |
Catalog Number
|
IW-PA1046 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A synthetic peptide corresponding to the C-terminal of
human ITGA4, identical to the related rat sequence. |
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
Positive Control |
Human mammary cancer, human intestinal cancer, HT-1080
cell. |
Cellular Localization |
Cytoplasmic |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C. Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Suitable. |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1. Fernandez-Ruiz, E.; Pardo-Manuel
de Villena, F.; Rubio, M. A.; Corbi, A. L.; Rodriguez de
Cordoba, S.; Sanchez-Madrid, F. :
Mapping of the human
VLA-alpha-4 gene to chromosome 2q31-q32. Europ. J.
Immun. 22: 587-590, 1992.
2. Jaspers, M.; Zhang, Z.;
Marynen, P.; Vekemans, S.; Aly, M. S.; Cuppens, H.;
Hillicker, C.; Cassiman, J.-J. :
Localization of the
genes encoding the alpha-2 and alpha-4 subunits of the human
VLA-receptors to chromosome 5q23-31 and 2q31-32
respectively. (Abstract) Cytogenet. Cell Genet.
58: 1870 only, 1991.
3. Zhang, Z.; Vekemans, S.; Aly,
M. S.; Jaspers, M.; Marynen, P.; Cassiman, J.-J. :
The gene for the alpha-4 subunit of the VLA-4 integrin maps to
chromosome 2q31-32. Blood 78: 2396-2399, 1991.
4 Matsunaga, T.; Takemoto, N.; Sato, T.;
Takimoto, R.; Tanaka, I.; Fujimi, A.; Akiyama, T.; Kuroda,
H.; Kawano, Y.; Kobune, M.; Kato, J.; Hirayama, Y.; Sakamaki,
S.; Kohda, K.; Miyake, K.; Niitsu, Y. :
Interaction between
leukemic-cell VLA-4 and stromal fibronectin is a decisive
factor for minimal residual disease of acute myelogenous
leukemia. Nature Med. 9: 1158-1165, 2003.
Note: Erratum: Nature Med. 11: 578 only, 2005. |
Images |
Immunohistochemical analysis of paraffin-embedded sections
Human mammary cancer using ITGA4 antibody
Staining ITGA4 in cytoplasm. DAB chromogenic reaction.
Immunocytochemistry analysis of HT-1080 cell using ITGA4
antibody
Immunohistochemical analysis of paraffin-embedded sections
Human intestinal cancer using ITGA4 antibody |
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