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Insulin IHC Antibody
Ready To Use
| Catalog Number | Size | Price | Availability |
| IW-MA1052 | 9 ml | $258 | Yes |
Description
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Insulin, synthesized by the beta cells of the islets of
Langerhans, consists of 2 dissimilar polypeptide chains, A
and B, which are linked by 2 disulfide bonds. The insulin
gene contains 3 exons and 2 introns; exon 2 encodes the
signal peptide, the B chain, and part of the C peptide,
while exon 3 encodes the remainder of the C peptide and the
A chain.
Localization of the human insulin gene to the distal end of
the short arm of chromosome 11.
Harper et al. (1981) and
Harper and Saunders (1981) assigned the insulin
gene to 11p15.5 by in situ hybridization.
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Catalog Number
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IW-MA1052 |
Quantity
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9 ml |
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Host
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Mouse
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Clone
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ISL-8J
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Isotype
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Mouse IgG1
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Immunogen
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Purity
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Purified by the goat anti-mouse IgG affinity chromatography. |
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Conjugate
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Unconjugated
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Species Reactivity
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Human,
mouse, rat.
Not tested in other species. |
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Positive Control
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Pancreas.
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Cellular Localization
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Cytoplasmic
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Form
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Ready to use solution. No further dilution needed. Serum
blocking step should be omitted.
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Storage
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Store at 2-8
°C.
Do not freeze.
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Applications
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IHC-P: Formalin fixed paraffin embedded tissue sections.
IHC-Fr: Not tested.
ICC: Not tested.
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Limitations
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This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user.
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Precautions
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Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes.
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References
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1. Harper, M. E.; Ullrich, A.; Saunders, G. F. :
Localization of the
human insulin gene to the distal end of the short arm of
chromosome 11.
Proc. Nat. Acad.
Sci. 78: 4458-4460, 1981.
2.
Owerbach, D.; Bell, G. I.; Rutter, W. J.; Shows, T. B. :
The insulin gene is
located on chromosome
3. Huerre, C.; Gilgenkrantz, S.;
Leonard, C.; Pictet, R.; Kaplan, J. C.; Junien, C. :
Regional assignment
of the structural gene for insulin to 11p15.1-11p15.5 by
deletion mapping. (Abstract)
Cytogenet. Cell
Genet. 37: 495, 1984.
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Images
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Immunohistochemical analysis of formalin fixed
paraffin-embedded rat pancreas using Insulin antibody
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