Catalog Number | Size | Price | Availability |
IW-MA1054 | 9 ml | $258 | Yes |
Description
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Laminin is a heterotrimeric extracellular matrix protein consisting of 3 chains: alpha-1,beta-1 and gamma-1, formerly called beta-2 (LAMA2). This gene is over 260, 000 base pairs and contains 64 exons. Laminin is similar with merosin, a basement membrane-associated protein found in placenta, striated muscle, and peripheral nerve, and both of them are members of the same family of basement membrane proteins. And merosin is the same as laminin M, a striated muscle-specific, basal-lamina-associated protein, it may play a primary role in the pathogenesis of that disorder.
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Catalog Number
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IW-MA1054
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Quantity
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9 ml
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Host |
Mouse
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Clone |
LAM-26
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Isotype |
Mouse IgG1
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Immunogen |
Human laminin
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Purity |
Purified by the goat anti-mouse IgG affinity chromatography
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Conjugate |
Unconjugated
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Species
Reactivity |
Human, pig, feline. Not tested in other species.
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Positive
Control |
Skin, kidney, skeletal muscle, small intestine.
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Cellular
Localization |
Basement membrane
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Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted.
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Storage |
Store at 2-8 °C. Do not freeze.
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Applications |
IHC-P:
Proteolytic Induced
Epitope Retrieval (PIER) (Proteinase K)
required on formalin fixed paraffin embedded tissue
sections.
IHC-Fr: Acetone
fixed frozen sections. ICC: Not tested.
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Limitations |
This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.
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Precautions |
Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.
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References |
1.
Zhang, X.; Vuolteenaho, R.; Tryggvason, K. :
Structure of the
human laminin alpha-2-chain gene (LAMA2), which is affected
in congenital muscular dystrophy. J. Biol. Chem.
271: 27664-27669, 1996.
2.
Ehrig, K.; Leivo, I.; Argraves, W. S.; Ruoslahti, E.;
Engvall, E. :
Merosin, a tissue-specific basement membrane protein, is a
laminin-like protein. Proc. Nat. Acad. Sci.
87: 3264-3268, 1990. 3. Arahata, K.; Hayashi, Y. K.; Mizuno, Y.; Yoshida, M.; Ozawa, E. : Dystrophin-associated glycoprotein and dystrophin co-localisation at sarcolemma in Fukuyama congenital muscular dystrophy. (Letter) Lancet 342: 623-624, 1993.
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Images |
Immunohistochemical analysis of acetone fixed frozen skin sections using
Laminin antibody
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