Muc-6 (Gastric Mucin) IHC Antibody

 

Ready To Use

 

Catalog Number Size Price Availability
IW-MA1043 9 ml $258 Yes

Description

The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Mucin gastric 6 (MUC6) is a large glycoprotein thought to play a major role in protecting the gastrointestinal tract from acid, proteases, pathogenic microorganisms and mechanical trauma. Expression of the gene was highest in the stomach and gallbladder, with weaker expression in the terminal ileum and right colon. Mucin glycoproteins play a key role in the normal function of the epithelium lining the gastrointestinal tract.

 

Catalog Number

IW-MA1043

 

Quantity

9 ml

 

Host

Mouse

 

Clone

GM-8A12

 

Isotype

Mouse IgG1

 

Immunogen

Mucin from human ovarian cystfluid.

 

Purity

Purified by the goat anti-mouse IgG affinity chromatography.

 

Conjugate

Unconjugated

 

Species Reactivity

Human. Not tested in other species.

 

Positive Control

Stomach, normal gastric mucosa

 

Cellular Localization

Cytoplasmic

 

Form

Ready to use solution. No further dilution needed. Serum blocking step should be omitted.

 

Storage

Store at 2-8 °C. Do not freeze.

 

Applications

IHC-P: Heat induced epitope retrieval is required on formalin fixed paraffin embedded sections.

IHC-Fr: Not tested.

ICC: Suitable.

 

Limitations

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

 

Precautions

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

 

References

1. Reid, C. J.; Harris, A. : Developmental expression of mucin genes in the human gastrointestinal system. Gut 42: 220-226, 1998.
2. Toribara, N. W.; Roberton, A. M.; Ho, S. B.; Kuo, W.-L.; Gum, E.; Hicks, J. W.; Gum, J. R., Jr.; Byrd, J. C.; Siddiki, B.; Kim, Y. S. : Human gastric mucin: identification of a unique species by expression
cloning. J. Biol. Chem. 268: 5879-5885, 1993.

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