Catalog Number | Size | Price | Availability |
IW-PA1069 | 9 ml | $258 | Yes |
Description
|
The receptor for advanced glycation end products (RAGE) is
a multi-ligand member of the immunoglobulin superfamily of
cell surface molecules. It interacts with distinct molecules
implicated in homeostasis, development and inflammation, and
certain diseases such as diabetes and Alzheimer's disease.
RAGE is also a central cell surface receptor for amphoterin
and EN-RAGE. RAGE is associated with sustained
NF-kappaB activation in the diabetic microenvironment and
has a central role in sensory neuronal dysfunction.
Moreover, RAGE propagates cellular dysfunction in
several inflammatory disorders and diabetes, and it also
functions as an endothelial adhesion receptor promoting
leukocyte recruitment. |
Catalog Number
|
IW-PA1069 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A synthetic peptide corresponding to a sequence mapping at
the N-terminal of human
advanced
glycosylation end-product-specific receptor(RAGE),
identical to the related rat and mouse sequence. |
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
Positive Control |
Rat lung |
Cellular Localization |
Cytoplasmic |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C. Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Suitable |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1.
Taguchi A,
Blood DC,
del Toro G,
Canet A,
Lee DC,
Qu W,
Tanji N,
Lu Y,
Lalla E,
Fu C,
Hofmann MA,
Kislinger T,
Ingram M,
Lu A,
Tanaka H,
Hori O,
Ogawa S,
Stern DM,
Schmidt AM. Blockade of RAGE-amphoterin
signalling suppresses tumour growth and metastases.
Nature.2000 May 18; 405(6784):354-60.
2.
Hofmann MA,
Drury S,
Fu C,
Qu W,
Taguchi A,
Lu Y,
Avila C,
Kambham N,
Bierhaus A,
Nawroth P,
Neurath MF,
Slattery T,
Beach D,
McClary J,
Nagashima M,
Morser J,
Stern D,
Schmidt AM. RAGE mediates a novel proinflammatory
axis: a central cell surface receptor for S100/calgranulin
polypeptides.
Cell. 1999 Jun 25;
97(7):889-901.
3.
Bierhaus A,
Haslbeck KM,
Humpert PM,
Liliensiek B,
Dehmer T,
Morcos M,
Sayed AA,
Andrassy M,
Schiekofer S,
Schneider JG,
Schulz JB,
Heuss D,
Neundorfer B,
Dierl S,
Huber J,
Tritschler H,
Schmidt AM,
Schwaninger M,
Haering HU,
Schleicher E,
Kasper M,
Stern DM,
Arnold B,
Nawroth PP. Loss of pain perception in diabetes
is dependent on a receptor of the immunoglobulin superfamily.
J Clin Invest. 2004 Dec; 114(12):1741-51.
4.
Chavakis T,
Bierhaus A,
Al-Fakhri N,
Schneider D,
Witte S,
Linn T,
Nagashima M,
Morser J,
Arnold B,
Preissner KT,
Nawroth PP. The pattern recognition receptor
(RAGE) is a counterreceptor for leukocyte integrins: a novel
pathway for inflammatory cell recruitment.
J Exp Med. 2003 Nov 17; 198(10):1507-15. |
Images |
Immunohistochemical analysis of formalin fixed paraffin-embedded
rat lung tissue section using
RAGE antibody
Immunohistochemistry staining of RAGE antibody (IW-PA1069) on formalin fixed paraffin-embedded mouse skin sections showing cytoplasmic staining pattern.
|
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