Catalog Number | Size | Price | Availability |
IW-PA1075 | 9 ml | $258 | Yes |
Description
|
Chen et al. (1998) determined the crystal structure of the
DNA complex of a 67-kD core fragment of the STAT1 homodimer,
lacking only the N-domain and the C-terminal transcriptional
activation domain, at 2.9-angstrom resolution.
Phosphorylation of Signal Transducer and Activator of
transcription 1(STAT 1) was also decreased in rheumatoid
arthritis lymphocytes. The transcription factor signal
transducer and activator of transcription-1 (STAT1) plays a
key role in immunity against mycobacterial and viral
infections. Activation of the signal transducers and
activators of transcription (STAT) pathway is important in
fibroblast growth factor (FGF) modulation of chondrocyte
proliferation and endochondral bone formation during
embryogenesis. |
Catalog Number
|
IW-PA1075 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A peptide mapping at the C-terminus of
human stat1(P91), identical to the related mouse and
rat sequence. |
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
Positive Control |
Human mammary cancer, Human carcinoma ventriculi. |
Cellular Localization |
Cytoplasmic |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C. Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested. |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1. Chapgier, A.; Boisson-Dupuis, S.; Jouanguy, E.; Vogt, G.;
Feinberg, J.; Prochnicka-Chalufour, A.; Casrouge, A.; Yang,
K.; Soudais, C.; Fieschi, C.; Santos, O. F.; Bustamante, J.;
and 10 others :
Novel STAT1 alleles in otherwise healthy patients with
mycobacterial disease. PLoS Genet. 2: e131,
2006. Note: Electronic Article
2. Ihle, J. N. :
STATs: signal
transducers and activators of transcription. Cell
84: 331-334, 1996.
3. Xiao, L.; Naganawa, T.;
Obugunde, E.; Gronowicz, G.; Ornitz, D. M.; Coffin, J. D.;
Hurley, M. M. :
Stat1 controls postnatal bone formation by regulating
fibroblast growth factor signaling in osteoblasts.
J. Biol. Chem. 279: 27743-27752, 2004. |
Images |
Immunohistochemical analysis of formalin fixed paraffin-embedded
human carcinoma ventriculi section using STAT1 antibody
Immunohistochemical analysis of formalin fixed paraffin-embedded
human mammary cancer section using STAT1 antibody |
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