Catalog Number | Size | Price | Availability |
IW-PA1108 | 9 ml | $258 | Yes |
Description
|
The transcription factor, signal transducer and activator
of transcription-3 (STAT-3) is the most pleiotropic member
of the signal transducer and activator of transcription
(STAT) family of transcription factors and mediates pivotal
responses for the cytokine family. The mouse STAT3 gene
contains 24 exons and spans 30 kb. The translation
initiation codon is in exon 2, and the stop codon is in exon
24. STAT3 is mapped to
17q21, it contributes to various physiological
processes. Hepatic STAT-3 signaling is thus essential for
normal glucose homeostasis and may provide new therapeutic
targets for diabetes mellitus. |
Catalog Number
|
IW-PA1108 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A synthetic peptide corresponding to a sequence at the
C-terminal of human STAT3, identical to the related rat and
mouse sequence. |
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
Positive Control |
Human mammary cancer |
Cellular Localization |
Cytoplasmic, nuclear. |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C. Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Suitable. |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1.
Bhattacharya, S.; Schindler, C. :
Regulation of Stat3
nuclear export. J. Clin. Invest. 111: 553-559,
2003.
2.
Miyoshi, K.; Cui, Y.; Riedlinger, G.; Robinson,
P.; Lehoczky, J.; Zon, L.; Oka, T.; Dewar, K.; Hennighausen,
L. : Structure of
the mouse Stat 3/5 locus: evolution from Drosophila to
zebrafish to mouse. Genomics 71: 150-155,
2001.
3.
Inoue, H.; Ogawa, W.; Ozaki, M.; Haga, S.;
Matsumoto, M.; Furukawa, K.; Hashimoto, N.; Kido, Y.; Mori,
T.; Sakaue, H.; Teshigawara, K.; Jin, S.; Iguchi, H.;
Hiramatsu, R.; LeRoith, D.; Takeda, K.; Akira, S.; Kasuga,
M. : Role of STAT-3
in regulation of hepatic gluconeogenic genes and
carbohydrate metabolism in vivo. Nature Med.
10: 168-174, 2004. |
Images |
Immunohistochemical analysis of formalin fixed paraffin-embedded
human mammary cancer section using STAT3 antibody. |
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