Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Human TH gene contains 13 primary exons and spans approximately 8 kb. TH is in the 11p15.5 region.

IW-MA1100

9 ml

Mouse

TH-100

Mouse IgG1

Rat tyrosine hydroxylase (TH)

Purified by the goat anti-mouse IgG affinity chromatography.

Unconjugated

Human, rat. Not tested in other species.

Brain (striatum, substantia nigra)

Cytoplasmic of dopamine neurons.

Ready to use solution. No further dilution needed. Serum blocking step should be omitted.

Store at 2-8 °C. Do not freeze.

IHC-P: Heat induced epitope retrieval is required on formalin fixed paraffin embedded sections.

IHC-Fr: Formalin or acetone fixed frozen sections.

ICC: Not tested.

This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.

Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.

1. Brilliant, M. H.; Niemann, M. M.; Eicher, E. M. : urine tyrosine hydroxylase maps to the distal end of chromosome 7 within a region conserved in mouse and man. J. Neurogenet. 4: 259-266, 1987.

2. Craig, S. P.; Buckle, V. J.; Craig, I. W.; Lamouroux, A.; Mallet, J. : Localization of the human tyrosine hydroxylase gene to chromosome 11p15. (Abstract) Cytogenet. Cell Genet. 40: 610 only, 1985.

3. Craig, S. P.; Buckle, V. J.; Lamouroux, A.; Mallet, J.; Craig, I. : Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. Cytogenet. Cell Genet. 42: 29-32, 1986.

Immunohistochemical staining of formalin fixed paraffin-embedded rat brain using TH antibody showing cytoplasmic staining pattern. DAB chromogen substrate.