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TNF-alpha IHC Antibody
Ready To Use
| Catalog Number | Size | Price | Availability |
| IW-PA1079 | 9 ml | $258 | Yes |
Description
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TNFα (Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
Catalog Number
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IW-PA1079 |
Quantity
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9 ml |
|
Host |
Rabbit |
|
Clone |
Polyclonal |
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Isotype |
IgG |
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Immunogen |
A synthetic peptide corresponding to a sequence at the C-terminal of human TNFalpha, different from the related mouse sequence by five amino acids, and rat sequence by seven amino acids. |
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Purity |
Immunogen affinity purified |
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Conjugate |
Unconjugated |
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Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
|
Positive Control |
Human mammary cancer |
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Cellular Localization |
Cytoplasmic |
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Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
|
Storage |
Store at 2-8
°C. Do not freeze. |
|
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested. |
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Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
|
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
|
References |
1. Shirai, T., Yamaguchi, H., Ito,
H., Todd, C. W., Wallace, R. B. Cloning and expression in
Escherichia coli of the gene for human tumour necrosis
factor.Nature 313: 803-806, 1985. 2. Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., Goeddel, D. V. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.Nature 312: 724-729, 1984. |
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Images |
Immunohistochemical analysis of formalin fixed paraffin-embedded
human mammary cancer section using TNFα antibody
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